Key result
A 47-year-old female with treated ductal carcinoma in situ developed malignant pericardial effusion and distant metastases 7 years later without local recurrence.
Why the study?
DCIS usually has a good prognosis, and distant metastasis in the absence of local recurrence is extremely rare.
Case Report (n=1)
Demonstrates that ductal carcinoma in situ can rarely lead to distant metastases, including malignant pericardial effusion, even without local recurrence.
Ductal carcinoma in situ (DCIS) is a precursor of invasive breast cancer (IBC) that may or may not lead to IBC. Although the incidence is increasing, it usually has a good prognosis. Local recurrence can occur in the form of DCIS or IBC. Distant metastasis is uncommon and in the absence of local recurrence is extremely rare. Here, we report a case of a 47-year-old female with DCIS, who, 7 years after treatment developed malignant pericardial effusion along with lung and marrow metastasis. This is the second reported case of distant multiple metastases without local recurrence in a known case of DCIS. This shows the possibility of aggressive behavior in DCIS that usually has a favorable prognosis.
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Aashita et al. (2023) conducted a case report in Ductal carcinoma in situ (DCIS) (n=1). Ductal carcinoma in situ (DCIS) was evaluated on Distant metastasis without local recurrence. A 47-year-old female with treated ductal carcinoma in situ developed malignant pericardial effusion and distant metastases 7 years later without local recurrence.
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