ABSTRACT Background Despite favourable survival prognosis, the main concern for ductal carcinoma in situ (DCIS) is local recurrence, especially progression to invasive cancer. This study identified factors associated with breast events following DCIS treatment. Methods Women with unilateral DCIS between 2000 and 2022 were identified from New Zealand Breast Cancer Foundation National Register. The primary endpoint was cumulative incidence of invasive breast cancer, ipsilateral (iIBC) or contralateral (iCBC). Secondary endpoints included ipsilateral breast event (IBE), in situ or invasive, and any breast event (IBE or CBC). Fine‐Gray models were used to identify the associated factors and estimate subdistribution hazard ratios (sHRs). Results Among 5740 patients followed for a median duration of 4.8 years, the 5‐ and 10‐year cumulative risks were 3.0% (95% CI, 2.4%, 3.5%) and 6.6% (95% CI, 5.7%, 7.6%) for iIBC, and 2.7% (95% CI, 2.2%, 3.3%) and 6.3% (95% CI, 5.4%, 7.3%) for iCBC, respectively. A higher risk of iIBC was observed in women aged under 45 at diagnosis (sHR, 1.81; 95% CI: 1.18, 2.79) or had DCIS size > 20 mm (sHR, 1.42; 1.05, 1.93), and a lower risk in those who received additional RT after BCS (HR: 0.61; 0.44, 0.84) or mastectomy (sHR, 0.21; 0.13, 0.32). Similar associations were observed for IBE and any breast event, for which surgical margin < 2 mm was also associated with a higher risk. Having surgery at a private facility, where higher‐risk patients were likely to be treated, was associated with a higher risk of iCBC. Conclusions DCIS size, surgical approach, and age at diagnosis influenced the risk of breast events after DCIS, which may be considered in efforts to improve treatment strategies for higher‐risk women.
Chen et al. (Thu,) studied this question.
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