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August 1, 2026European PsychiatryOpen Access

Age of Onset of first depressive episode requiring hospitalisation, Clinical Characteristics, and Response to Electroconvulsive Therapy

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Authors

TATor ArnisonNNNatalie NordinANAxel Nordenskjöld

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Overview

Nationwide register-based study examining age of onset and its impact on ECT response in hospitalized patients.

Key Points

  • To investigate the predictive value of age at onset of depressive episodes on ECT response and remission rates.
  • Nationwide register-based study in Sweden including 14,141 patients
  • Examined response using Clinical Global Impression-Improvement scale and remission via Montgomery-Åsberg Depression Rating Scale-Self report
  • Utilized hierarchical logistic regression and causal mediation analyses.
  • Higher response rates in late-onset depression (84.9%) compared to early-onset (64.6%)
  • Late onset associated with higher odds of response and remission, independent of chronological age
  • Early-onset disadvantage linked to psychiatric comorbidity and treatment complexity.

Cite This Study

Arnison et al. (2026) studied this question.

synapsesocial.com/papers/6a6d980be258b358b3c6ada3https://doi.org/10.1192/j.eurpsy.2026.12248
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