Retrospective study examines glycemic status and its relations to clinical outcomes in MS, indicating complexity of metabolic effects.
Key Points
To investigate the associations of glycemic regulation with disability, relapse activity, inflammatory markers, and metabolic characteristics in multiple sclerosis.
Retrospective single-center observational study including 455 patients with MS aged 18–65 years.
Categorized patients into normoglycemia, prediabetes, and diabetes based on ADA criteria.
Evaluated associations using group comparisons, Spearman correlation analyses, and multivariable regression models.
Significant differences observed in clinical and metabolic parameters across glycemic groups (all p < 0.05).
HbA1c, FPG, TyG index, and inflammatory markers correlated with higher EDSS scores but inversely with ARR (all p < 0.05).
Post-adjustment, prediabetes and diabetes were not independently linked to EDSS or ARR, with age, disease duration, and MS phenotype being key factors.