Key result
24-hour ambulatory ECG monitoring revealed pathological findings in 35.7% of patients with idiopathic long QT syndrome compared to 0% of healthy controls (p < 0.03).
Why the study?
Does 24-hour ambulatory ECG monitoring detect pathological findings in patients with idiopathic long QT syndrome compared to healthy controls?
Case-Control (n=28)
Does 24-hour ambulatory ECG monitoring detect pathological findings in patients with idiopathic long QT syndrome compared to healthy controls?
Absolute Event Rate: 35.7% vs 0%
p-value: p=< 0.03
24-hour ambulatory ECG monitoring yields significant diagnostic information by detecting pathological arrhythmias in a substantial proportion of patients with suspected LQTS.
Ambulatory ECG may aid idiopathic LQTS diagnosis; leaves open need for larger validation before clinical adoption.
The idiopathic long QT syndrome (LQTS) is an infrequently occurring disorder. It has major clinical impact as patients are prone to syncope, ventricular tachyarrhythmias and sudden arrhythmogenic cardiac death. This paper reports the value of ambulatory electrocardiogram (ECG) monitoring as a diagnostic tool to establish the diagnosis of LQTS. 14 patient with idiopathic LQTS were studied. The results were compared to those of 14 age- and sex-matched healthy control individuals. A 24-hour ambulatory ECG tracing was obtained in each individual. 5/14 patients with LQTS had pathological findings during ambulatory ECG monitoring (2 patients with episodes of torsade de pointes tachycardia, 2 patients with T-wave alternans and 1 patient with bradycardia due to an intermittent SA block), whereas all control persons had normal ambulatory ECG recordings (p < 0.03). Thus, ambulatory ECG recordings may contribute significant diagnostic information in patients with suspected LQTS.
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Eggeling et al. (2008) conducted a case-control in Idiopathic long QT syndrome (LQTS) (n=28). 24-hour ambulatory ECG monitoring vs. Healthy controls was evaluated on Pathological findings during ambulatory ECG monitoring (p=< 0.03). 24-hour ambulatory ECG monitoring revealed pathological findings in 35.7% of patients with idiopathic long QT syndrome compared to 0% of healthy controls (p < 0.03).
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