Key result
In patients with advanced chronic kidney disease (stage G4-G5), high pulse pressure (≥65 mmHg) was associated with a significantly greater decline in estimated glomerular filtration rate over 12 months compared to low pulse pressure (-6.2 vs -2.9 mL/min/1.73m2, p=0.0481).
Why the study?
Is high pulse pressure associated with decreased renal function across different stages of chronic kidney disease?
Cohort (n=104)
No
Is high pulse pressure associated with decreased renal function across different stages of chronic kidney disease?
Absolute Event Rate: -6.2% vs -2.9%
p-value: p=0.0481
High pulse pressure may worsen renal decline in advanced CKD stages; extends prior associations but remains hypothesis-generating.
Background: In our previous study, we showed that high pulse pressure (PP) is associated with decreased renal function in chronic kidney disease (CKD) patients. In recent years, there were a few reports that CKD stage classification focused on glomerular filtration rate, which is associated with the occurrence of cardiovascular disease, deterioration of renal prognosis, and life prognosis. We aim to examine the relationship between increased PP and renal function according to each CKD stage classification. Methods: The present study includes 104 participants with CKD (stage G3a-G5) who visited the Nephrology Medicine Department of Yokosuka Kyousai Hospital between September 2006 and October 2011. The participants were categorized on the basis of PP: ≥65 mmHg was the High PP group, and
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Kose et al. (2018) conducted a cohort in Chronic Kidney Disease (n=104). High pulse pressure (≥65 mmHg) vs. Low pulse pressure (<65 mmHg) was evaluated on Change in estimated glomerular filtration rate (ΔeGFR) at 12 months in CKD stage G4-G5 (p=0.0481). In patients with advanced chronic kidney disease (stage G4-G5), high pulse pressure (≥65 mmHg) was associated with a significantly greater decline in estimated glomerular filtration rate over 12 months compared to low pulse pressure (-6.2 vs -2.9 mL/min/1.73m2, p=0.0481).
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