Key result
A high-fat diet significantly increased primary mammary tumor growth rates, terminal weights, and adipose tissue inflammation compared to a low-fat diet in a mouse model of breast cancer.
Why the study?
Does a high-fat diet enhance mammary carcinogenesis and local inflammation in a mouse model of breast cancer?
Population
40 four-week old female immunocompetent MMTV-PyMT mice (20/group)
Comparison
High-fat diet for eight weeks vs Low-fat (LF; 16% kcal) diet for eight weeks
Design
Preclinical, randomized
Follow-up
8 weeks
Authors
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HF diet effects in PyMT mice are hypothesis-generating; leaves open mechanistic and translational relevance to human breast cancer.
RCT (n=40)
randomized
Does a high-fat diet enhance mammary carcinogenesis and local inflammation in a mouse model of breast cancer?
A high-fat diet induces mammary adipose tissue inflammation, enhances macrophage recruitment, and increases tumor vascular density, promoting breast cancer progression in a preclinical model.
Cowen et al. (2015) conducted an RCT in breast cancer (n=40). High-fat/high-calorie diet vs. Low-fat diet (16% kcal) was evaluated on mammary carcinogenesis and local inflammation. A high-fat diet significantly increased primary mammary tumor growth rates, terminal weights, and adipose tissue inflammation compared to a low-fat diet in a mouse model of breast cancer.
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