Why the study?
It remains unclear when during survivorship left atrial dysfunction becomes detectable in childhood cancer survivors treated with anthracyclines.
Does prior anthracycline chemotherapy impair left atrial phasic strain in childhood cancer survivors compared to healthy controls?
Population
92 childhood cancer survivors aged 4-32 years and 96 age-matched healthy controls
Comparison
Childhood cancer survivors treated with anthracyclines vs age-matched healthy controls across age groups
Design
Retrospective observational case-control study
Key result
Anthracycline chemotherapy exposure in childhood cancer survivors was associated with significantly reduced left atrial reservoir, conduit, and pump strains in young adulthood compared to controls.
Authors
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Strain assessment may detect subclinical dysfunction in young adult survivors; leaves open prospective outcome validation before routine use.
Case-Control (n=188)
Observers blinded to clinical data
Yes
Does prior anthracycline chemotherapy impair left atrial phasic strain in childhood cancer survivors compared to healthy controls?
p-value: p=<0.01
Age-stratified left atrial strain assessment can detect subclinical cardiac dysfunction in young adult childhood cancer survivors treated with anthracyclines, even when conventional diastolic indices remain preserved.
Sato et al. (2026) conducted a case-control in Childhood cancer survivors treated with anthracyclines (n=188). Anthracycline chemotherapy vs. Age-matched healthy controls was evaluated on Left atrial phasic strain (reservoir, conduit, and pump strains) (p=<0.01). Anthracycline chemotherapy exposure in childhood cancer survivors was associated with significantly reduced left atrial reservoir, conduit, and pump strains in young adulthood compared to controls.
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