Key result
Prior anthracycline exposure in asymptomatic childhood cancer survivors did not result in significant differences in left ventricular longitudinal or circumferential dyssynchrony compared to healthy controls.
Why the study?
Left ventricular contraction patterns had not been evaluated in asymptomatic childhood cancer survivors using two-dimensional speckle tracking echocardiography.
Does prior anthracycline therapy cause left ventricular dyssynchrony in asymptomatic childhood cancer survivors compared to healthy controls?
Cross-Sectional (n=234)
No
Does prior anthracycline therapy cause left ventricular dyssynchrony in asymptomatic childhood cancer survivors compared to healthy controls?
In asymptomatic childhood cancer survivors treated with anthracyclines, 2D speckle tracking echocardiography did not reveal clinically significant left ventricular dyssynchrony compared to healthy controls, despite reduced global longitudinal strain.
Answers are grounded in this paper and cite their sources.
LV dyssynchrony not increased in asymptomatic survivors; leaves open its role in anthracycline cardiotoxicity progression.
The purpose of this study was to investigate left ventricular contraction patterns in asymptomatic Childhood cancer survivors (CCS) using two-dimensional speckle tracking echocardiography (2DSTE). Left ventricular longitudinal and circumferential myocardial parameters were assessed using 2DSTE, in asymptomatic CCS and age matched healthy controls. Time to peak (T2P) systolic strain was quantified. Dyssynchrony index (DI) was measured by calculating the standard deviation of T2P systolic strain of six segments in each view. Difference between T2P systolic longitudinal strain of septal and lateral wall was also assessed as a parameter for dyssynchrony. We included 115 CCS with a median age of 17.2 years (range 5.6-39.5) and a median follow up of 11.3 years (range 4.9-29.5) and 119 controls. Conventional echocardiographic parameters and global longitudinal strain were significantly decreased in CCS compared to controls (p < 0.01 and p = 0.02, respectively). Dyssynchrony index did not differ between CCS and controls. There was a clinically insignificant smaller absolute difference between T2P systolic longitudinal of septal and lateral wall in CCS compared to controls. We showed no difference in longitudinal or circumferential left ventricular dyssynchrony in CCS compared to controls using 2DSTE. Future research should focus on assessing dyssynchrony in more segments and a larger CCS population, using both 2D and 3DSTE.
No takes yet. Share an insight, caveat, or question.
Pourier et al. (2021) conducted a cross-sectional in Childhood cancer survivors treated with anthracyclines (n=234). Anthracycline therapy vs. Healthy age-matched controls was evaluated on Longitudinal dyssynchrony index (% heart cycle) (p=0.41). Prior anthracycline exposure in asymptomatic childhood cancer survivors did not result in significant differences in left ventricular longitudinal or circumferential dyssynchrony compared to healthy controls.
Synapse has enriched 10 related papers. Consider them for comparative context: