Why the study?
Left ventricular contraction patterns had not been evaluated in asymptomatic childhood cancer survivors using two-dimensional speckle tracking echocardiography.
Does prior anthracycline therapy cause left ventricular dyssynchrony in asymptomatic childhood cancer survivors compared to healthy controls?
Population
115 asymptomatic childhood cancer survivors and 119 age matched healthy controls
Comparison
Childhood cancer survivors vs age matched healthy controls
Design
Retrospective cross-sectional study
Follow-up
Median 11.3 years (range 4.9-29.5)
Key result
Prior anthracycline exposure in asymptomatic childhood cancer survivors did not result in significant differences in left ventricular longitudinal or circumferential dyssynchrony compared to healthy controls.
Authors
Loading...
LV dyssynchrony not increased in asymptomatic survivors; leaves open its role in anthracycline cardiotoxicity progression.
Cross-Sectional (n=234)
No
Does prior anthracycline therapy cause left ventricular dyssynchrony in asymptomatic childhood cancer survivors compared to healthy controls?
Absolute Event Rate: 3.05% vs 3.18%
p-value: p=0.41
In asymptomatic childhood cancer survivors treated with anthracyclines, 2D speckle tracking echocardiography did not reveal clinically significant left ventricular dyssynchrony compared to healthy controls, despite reduced global longitudinal strain.
Pourier et al. (2021) conducted a cross-sectional in Childhood cancer survivors treated with anthracyclines (n=234). Anthracycline therapy vs. Healthy age-matched controls was evaluated on Longitudinal dyssynchrony index (% heart cycle) (p=0.41). Prior anthracycline exposure in asymptomatic childhood cancer survivors did not result in significant differences in left ventricular longitudinal or circumferential dyssynchrony compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: