Why the study?
Does two-dimensional speckle tracking echocardiography detect subclinical left ventricular systolic dysfunction better than standard LVEF in adult survivors of childhood cancer?
Population
134 adult survivors of childhood, adolescent, and young adult cancer previously treated with anthracyclines…
Comparison
Two-dimensional speckle tracking echocardiography vs Standard echocardiographic parameters
Design
Cross-sectional
Key result
In adult cancer survivors treated with anthracyclines, prior mediastinal radiotherapy was associated with a higher prevalence of abnormal global longitudinal strain (36.5% vs 14.6%, p=0.004).
Authors
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May support intensified GLS monitoring in anthracycline survivors with mediastinal radiotherapy; leaves open prospective validation.
Cross-Sectional (n=134)
Does two-dimensional speckle tracking echocardiography detect subclinical left ventricular systolic dysfunction better than standard LVEF in adult survivors of childhood cancer?
Absolute Event Rate: 36.5% vs 14.6%
p-value: p=0.004
Two-dimensional speckle tracking echocardiography frequently detects subclinical left ventricular systolic dysfunction in adult cancer survivors despite a normal LVEF, particularly in those who received mediastinal radiotherapy.
Yu et al. (2016) conducted a cross-sectional in Adult survivors of childhood, adolescent, and young adult cancer (n=134). Mediastinal radiotherapy vs. No mediastinal radiotherapy was evaluated on Prevalence of abnormal global longitudinal strain (GLS ≤ 16%) (p=0.004). In adult cancer survivors treated with anthracyclines, prior mediastinal radiotherapy was associated with a higher prevalence of abnormal global longitudinal strain (36.5% vs 14.6%, p=0.004).