Key result
Anthracycline therapy was associated with significantly reduced 3D global area strain (-43.3% vs -45.8%, p=0.008) compared to healthy controls in patients with preserved ejection fraction.
Why the study?
Does 3D speckle tracking echocardiography detect early LV endocardial dysfunction in patients with preserved EF after anthracycline chemotherapy?
Observational (n=70)
Does 3D speckle tracking echocardiography detect early LV endocardial dysfunction in patients with preserved EF after anthracycline chemotherapy?
Absolute Event Rate: -43.3% vs -45.8%
p-value: p=0.008
3D speckle tracking area strain can detect early, subclinical LV endocardial dysfunction in patients treated with anthracyclines despite preserved ejection fraction.
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May support subclinical cardiotoxicity detection by 3D strain; leaves open prospective outcome validation before practice change.
Miyoshi et al. (2013) conducted an observational in Preserved ejection fraction after receiving anthracycline (n=70). Anthracycline chemotherapy vs. Healthy controls was evaluated on 3D Global Area Strain (3D-GAS) (p=0.008). Anthracycline therapy was associated with significantly reduced 3D global area strain (-43.3% vs -45.8%, p=0.008) compared to healthy controls in patients with preserved ejection fraction.