Key result
Each doubling of serum interleukin-2 levels was independently associated with a 21.2% higher risk of 1-year major adverse cardiovascular events in patients hospitalized with acute decompensated heart failure.
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Editorial analysis shows elevated interleukin-2 predicts adverse cardiovascular events in acute decompensated heart failure, highlighting myocardial T-cell activation.
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Adachi et al. (2026) conducted an editorial in Acute decompensated heart failure (n=872). Elevated serum interleukin-2 (IL-2) levels vs. Lower serum IL-2 levels was evaluated on 1-year major adverse cardiovascular events (MACE) (21.2% higher risk per doubling). Each doubling of serum interleukin-2 levels was independently associated with a 21.2% higher risk of 1-year major adverse cardiovascular events in patients hospitalized with acute decompensated heart failure.
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