What question did this study set out to answer?

This study aims to compare the effects of sugammadex and neostigmine on postoperative respiratory complications and healthcare utilization.

December 23, 2022Anaesthesia

The effects of sugammadex vs. neostigmine on postoperative respiratory complications and advanced healthcare utilisation: a multicentre retrospective cohort study

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Retrospective cohort study investigates postoperative complications and healthcare use in adults utilizing sugammadex or neostigmine.

This study aims to compare the effects of sugammadex and neostigmine on postoperative respiratory complications and healthcare utilization.
Multicentre retrospective cohort study including adult patients administered with sugammadex or neostigmine from January 2016 to June 2021.
Primary outcome assessed was postoperative respiratory complications within 7 days.
Secondary outcomes included advanced healthcare utilization such as ICU admission and hospital readmission.
Out of 83,250 patients, 5746 (6.9%) experienced postoperative respiratory complications with no significant association with the reversal drug (adjusted OR 1.01, 95% CI 0.94-1.08, p=0.76).
8372 (10.5%) patients required advanced healthcare utilization, also showing no association with the drug used (adjusted OR 0.95, 95% CI 0.89-1.01, p=0.11).
Equivalence testing confirmed that sugammadex and neostigmine had equivalent effects on both outcomes.

Suleiman et al. (2022) studied this question.

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