August 1, 1991European Heart Journal
Degenerative aortic regurgitation
Key result
In patients with anulo-aortic ectasia, complete replacement of the ascending aorta improved 6-year actuarial survival compared to partial repair (81% vs 59%, P<0.05).
Why the study?
Does complete replacement of the ascending aorta improve long-term outcomes compared to partial repair or valve replacement alone in patients with degenerative aortic regurgitation and varying degrees of aortic dilatation?
Population
102 patients operated on for isolated chronic aortic regurgitation of degenerative origin between 1974 and…
Comparison
Aortic valve replacement with or without partial… vs Comparisons between subgroups based on aortic…
Design
Cohort
Follow-up
mean 58 months
Authors
Discussion
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Implication
Degenerative AR may guide etiology-specific surgical planning; leaves open applicability to modern cohorts and techniques.
Study Design
Type
Cohort (n=102)
Structured PICO
Does complete replacement of the ascending aorta improve long-term outcomes compared to partial repair or valve replacement alone in patients with degenerative aortic regurgitation and varying degrees of aortic dilatation?
P
Population
102 patients operated on for isolated chronic aortic regurgitation of degenerative origin between 1974 and 1989, followed for a mean of 58 months.
E
Exposure
Aortic valve replacement with or without partial or complete replacement of the ascending aorta (Cabrol technique).
C
Comparator
Comparisons between subgroups based on aortic root diameter (Group Ia vs Ib) and surgical technique (partial repair vs complete replacement in Group II).
O
Outcome
Complications related to the ascending aorta (aortic dissection, aneurysm development, reoperation) and actuarial survival.hard clinical
Main Result
Absolute Event Rate: 81% vs 59%
p-value: p=< 0.05
In patients with degenerative aortic regurgitation and aortic dilatation, complete replacement of the ascending aorta provides better long-term survival and freedom from aortic complications compared to partial repair or valve replacement alone.
Cite This Study
Michel et al. (1991) conducted a cohort in Degenerative aortic regurgitation (n=102). Complete replacement of the ascending aorta vs. Partial repair was evaluated on 6-year actuarial survival (p=< 0.05). In patients with anulo-aortic ectasia, complete replacement of the ascending aorta improved 6-year actuarial survival compared to partial repair (81% vs 59%, P<0.05).