Key result
Using a new non-invasive analysis, local pulse wave velocity was 20% higher and reflected waves arrived 35% earlier in patients over 50 years compared to those under 50 years.
Cross-Sectional (n=28)
No
Effect estimate: higher by 20%
p-value: p=< 0.05
May aid non-invasive vascular aging assessment; leaves open prospective validation before clinical adoption.
was assessed by the estabilished foot to foot method (Complior Artech, Paris); PWVba and CAVI were obtained by a commercially available system (Vasera Fukuda, Tokyo), recording simultaneously brachial and tibial sphygmogram, ECG and phonocardiogram (PGC).CAVI is derived from the stiffness index Beta, according to Bramwell-Hill formula.Results: PWba was significantly correlated with PWVcf (r Z 0.785, p<0.001); in Bland Altman analysis, all points but two were included into AE 2SD of mean difference (mean differenceZ 0.804 AE 2.17 m/s).CAVI, PWVba, PWVcf were directly correlated with age (r Z 0.778, 0.595, 0.687; p<0.001) and pulse pressure (r Z 0.504, 0.300, 0.422; p<0.001).Conclusions: PWVba, an integrated index of aortic and femoro-tibial stiffness, shows good agreement with PWVcf.CAVI index seems to provide the best associations with age and pulse pressure.
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Khir et al. (2008) conducted a cross-sectional in Healthy cardiovascular function (n=28). Age > 50 years vs. Age < 50 years was evaluated on Local Pulse Wave Velocity (LPWV) (higher by 20%, p=< 0.05). Using a new non-invasive analysis, local pulse wave velocity was 20% higher and reflected waves arrived 35% earlier in patients over 50 years compared to those under 50 years.
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