Key result
An abnormal ECG stress test (OR 3.9; 95% CI 1.3-11.4; P=0.008) and abnormal myocardial scintigraphy (OR 3.8; 95% CI 1.3-11.0; P=0.009) predicted cardiac events in asymptomatic diabetic patients.
Why the study?
Does combining myocardial scintigraphy with a maximal ECG stress test improve the detection of silent coronary stenoses and prediction of cardiovascular events in asymptomatic patients with diabetes compared to ECG stress test alone?
Cohort (n=262)
Does combining myocardial scintigraphy with a maximal ECG stress test improve the detection of silent coronary stenoses and prediction of cardiovascular events in asymptomatic patients with diabetes compared to ECG stress test alone?
Odds Ratio: 3.9 (95% CI 1.3–11.4)
p-value: p=0.008
In asymptomatic patients with diabetes, while adding myocardial scintigraphy to an ECG stress test detects more silent coronary stenoses, the ECG stress test alone has a high negative predictive value (97%) for cardiac events and is recommended as the first-line test.
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May aid silent ischemia detection in asymptomatic diabetes; leaves open whether routine screening improves outcomes.
Cosson et al. (2004) conducted a cohort in Diabetes (n=262). Abnormal ECG stress test vs. Normal ECG stress test was evaluated on Cardiac events (OR 3.9, 95% CI 1.3-11.4, p=0.008). An abnormal ECG stress test (OR 3.9; 95% CI 1.3-11.4; P=0.008) and abnormal myocardial scintigraphy (OR 3.8; 95% CI 1.3-11.0; P=0.009) predicted cardiac events in asymptomatic diabetic patients.
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