Key result
Distal symmetric polyneuropathy in type 2 diabetes was not associated with significant differences in photopic, mesopic, or scotopic pupil diameters compared to non-neuropathic patients (p>0.05).
Why the study?
Pupillary dysfunction manifests in diabetic autonomic neuropathy, making non-invasive static pupillometry a potential indicator for the early detection and evaluation of neuropathy in type 2 diabetes mellitus.
Does infrared static pupillography detect differences in pupil response between type 2 diabetes patients with and without distal symmetric polyneuropathy?
Case-Control (n=480)
Does infrared static pupillography detect differences in pupil response between type 2 diabetes patients with and without distal symmetric polyneuropathy?
Infrared static pupillography is not a reliable method for the early diagnosis of distal symmetric polyneuropathy in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Static pupillometry may support early diabetic neuropathy detection; leaves open diagnostic accuracy and clinical utility pending prospective studies.
Aim: Diabetic autonomic neuropathy is manifested by pupillary dysfunction in the eye; so pupillary assessment can be vital for early detection. We aim to determine the relationship between diabetic polyneuropathy and pupil response for evaluating the presence of neuropathy via static pupillometer that is a non-invasive and quantitative method. This method could be used as an indicator for early diagnosis of neuropathy in diabetic patients. Methods: This case-control study was planned on 420 patients. All participants have been diagnosed with Type 2 Diabetes Mellitus and were referred to Neurology Department. The first group includes 60 patients who have type 2 diabetes mellitus with distal symmetric polyneuropathy (DPN). Second group includes 212 diabetic patients who don't have polyneuropathy. Besides, age-sex matched 208 non-diabetic controls were included in the study. Mesopic, scotopic and photopic pupil measurements were recorded via infrared static pupillography.Results: The photopic pupil diameter was 3.72 (0.86) mm, 3.64 (0.78) mm, 3.74 (0.78) mm and mesopic pupil diameter were 4.06 (0.76) mm, 4.22 (0.80), 4.39 (0.83) mm and scotopic pupil diameter was 4.58 (0.76) mm, 4.56 (0.84) mm, 4.77 (0.85) mm respectively in DPN group, non-neuropathic diabetic group, and control group. There was no statistically significant difference in groups (p>0.05) except for mesopic and scotopic pupil diameters between control and non-neuropathic diabetic group (p=0.03 and p=0.01, respectively).Conclusion: Pupillographic methods are not as reliable as diabetic autonomic neuropathy in the early diagnosis of DPN.
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Şahin et al. (2019) conducted a case-control in Type 2 Diabetes Mellitus (n=480). Distal symmetric polyneuropathy (DPN) vs. Non-neuropathic diabetic patients and non-diabetic controls was evaluated on Mesopic, scotopic and photopic pupil measurements via infrared static pupillography (p=>0.05). Distal symmetric polyneuropathy in type 2 diabetes was not associated with significant differences in photopic, mesopic, or scotopic pupil diameters compared to non-neuropathic patients (p>0.05).
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