Key result
Acetylcholine spasm provocation tests were performed safely with 0 complications in 13 rest angina patients with well-controlled bronchial asthma, despite the off-label use.
Why the study?
Acetylcholine use is contraindicated in patients with bronchial asthma, leaving its usefulness and safety in rest angina patients with bronchial asthma unclear.
Is it safe to perform acetylcholine spasm provocation tests in rest angina patients with well-controlled bronchial asthma?
Population
495 rest angina patients undergoing acetylcholine spasm provocation tests
Comparison
Patients with bronchial asthma vs without bronchial asthma
Design
Observational study
Authors
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ACh spasm testing may be feasible in select rest angina patients with BA; leaves open need for prospective safety confirmation before any practice change.
Observational (n=495)
No
Is it safe to perform acetylcholine spasm provocation tests in rest angina patients with well-controlled bronchial asthma?
Absolute Event Rate: 0% vs 1.7%
Acetylcholine spasm provocation tests can be safely performed in rest angina patients with well-controlled bronchial asthma, despite current medical package insert contraindications.
Shozo Sueda (2020) conducted an observational in Rest angina (n=495). Bronchial asthma vs. Patients without bronchial asthma was evaluated on Major complications during acetylcholine spasm provocation tests. Acetylcholine spasm provocation tests were performed safely with 0 complications in 13 rest angina patients with well-controlled bronchial asthma, despite the off-label use.
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