Key result
Adding HRV and HRT parameters increases CV event prediction sensitivity by ~48 points in hypertension.
Why the study?
The study was conducted to develop a method to identify patients with degree II arterial hypertension at increased risk of myocardial infarction, stroke, and cardiovascular death over 1-3 years using heart rate variability and turbulence parameters.
Does the assessment of heart rate variability and heart rate turbulence identify patients with arterial hypertension at increased risk of adverse cardiovascular events?
Cohort (n=240)
Does the assessment of heart rate variability and heart rate turbulence identify patients with arterial hypertension at increased risk of adverse cardiovascular events?
Assessment of heart rate variability and heart rate turbulence provides high sensitivity and specificity for predicting adverse cardiovascular events in patients with grade II arterial hypertension.
Objective. To develop a method for isolating a group of patients with arterial hypertension of the II degree with an increased risk of the total number of myocardial infarctions, strokes, lethal outcomes from cardiovascular diseases (CVD) in the next 1-3 years, taking into account the assessment of heart rate variability and heart rate turbulence parameters. Materials and methods . In the course of a prospective clinical study 214 patients with arterial hypertension (AH) of the II degree aged 35 to 70 (57,7±7,6) years and 26 practically healthy individuals aged 30-60 (51,7±7,7) years were examined. All were given a comprehensive examination, including Holter monitoring (HM), electrocardiography (ECG), echocardiography (EchoCG). Statistical processing of the results was carried out using the “Statistica 10.0” software. Results. The total number of myocardial infarctions, strokes, and lethal outcomes registered in patients with arterial hypertension of the II degree over a period of 2.6±1.3 years was estimated, the factors associated with their development were determined. A method has been developed to identify a group of patients with arterial hypertension of the II degree who have an increased risk of developing adverse cardiovascular events over the next 1-3 years, it has been shown that its sensitivity is 90.9%; specificity is 95.8%. Conclusion . It is shown that the use of heart rate variability (HRV) and heart rate turbulence (HRT) parameters provides a significant increase in the sensitivity and specificity of the identification of a group with an increased risk of developing the total number of strokes, myocardial infarctions and lethal outcomes in the next 1-3 years.
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Aleynikova et al. (2023) conducted a cohort in Arterial hypertension of the II degree (n=240). Prognostic model including heart rate variability (HRV) and heart rate turbulence (HRT) parameters vs. Prognostic model without HRV and HRT parameters was evaluated on Sensitivity for predicting adverse cardiovascular events (myocardial infarctions, strokes, lethal outcomes) (p=0.0128). The inclusion of heart rate variability and heart rate turbulence parameters in the prognostic model significantly increased its sensitivity from 42.9% to 90.9% for predicting adverse cardiovascular events in patients with arterial hypertension.
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