Key result
Non-dipper hypertension was associated with significantly lower heart rate turbulence slope and higher turbulence onset compared to dipper hypertension, indicating greater autonomic dysfunction.
Why the study?
Hypertensive patients demonstrate autonomic dysfunction associated with HRV and HRT, prompting an investigation into HRV and HRT measurement alterations in dipper versus non-dipper hypertension.
Observational (n=123)
Yes
Absolute Event Rate: 3.26% vs 6.48%
p-value: p=<0.001
Supports link between non-dipping and autonomic dysfunction; hypothesis-generating and should not yet alter practice.
Background/aim: Hypertensive patients have shown autonomic dysfunction that is closely associated with the measurements of heart rate variability (HRV) and heart rate turbulence (HRT). We aimed to show the alterations of HRV and HRT measurements in patients with both dipper and non-dipper hypertension. Materials and methods: This was a retrospective study consisting of one hundred and twenty-three participants (mean age ± SD, 55.7 ± 14.8 years; range, 18–90 years). The participants were divided into two groups: Group1: The patients with dipper hypertension, Group2: The patients with non-dipper hypertension. Two cardiologists performed HRV and HRT using 24-h electrocardiography (ECG) Holter and ambulatory blood pressure monitoring (ABPM) of patients. Results: The results indicated that patients in group 2 had higher low frequency power/high frequency power ratio (LF/HF), lower high frequency power (HF) , root mean square of standard deviation (RMSSD) values than group 1 (p = 0.007, p = 0.008, and p = 0.002, respectively). Group 2 also showed higher heart rate turbulence onset (HRTTO) and lower heart rate turbulence slope (HRTTS) values than Group 1 (p = 0.004, p = 0.001, respectively). We performed multivariate analysis and observed that HRTTS and HRTTO have statistically significant associations with the presence of dipper or non-dipper hypertension [F = 7.755, p = 0.001], LF/HF [F = 7.868, p = 0.001], and HF [F = 4.081, p = 0.020]. Conclusion: This study shows a statistically significant difference in HRT measurements between dipper and non-dipper hypertensive patients. Deteriorated autonomic circadian rhythm and autonomic functions may contribute to these results.
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Alp et al. (2021) conducted an observational in Hypertension (n=123). Non-dipper hypertension vs. Dipper hypertension was evaluated on Heart rate turbulence slope (HRTTS) (p=<0.001). Non-dipper hypertension was associated with significantly lower heart rate turbulence slope and higher turbulence onset compared to dipper hypertension, indicating greater autonomic dysfunction.
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