Key result
Low aerobic capacity in elderly adults was associated with adverse cardiovascular parameters, including a lower E/A ratio >0.8 (76% vs 35%; OR 4.1, 95% CI 1.7-9.5, P=0.001).
Why the study?
Does high aerobic capacity correlate with better cardiovascular function and metabolomic profiles in elderly adults without known cardiovascular disease?
Observational (n=141)
Does high aerobic capacity correlate with better cardiovascular function and metabolomic profiles in elderly adults without known cardiovascular disease?
Odds Ratio: 4.1 (95% CI 1.7–9.5)
Absolute Event Rate: 76% vs 35%
p-value: p=0.001
Higher aerobic capacity in elderly adults is associated with better cardiovascular function and a favorable metabolomic profile, including lower accumulation of acyl-carnitines and specific amino acids.
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Metabolic differences by aerobic capacity may refine risk stratification; leaves open causal mediation of outcomes in prospective studies.
Koh et al. (2018) conducted an observational in Elderly adults without cardiovascular disease (n=141). Low aerobic capacity (low VO2) vs. High aerobic capacity (high VO2) was evaluated on Ratio of peak velocity flow in early diastole to peak velocity flow in late diastole by atrial contraction of >0.8 (OR 4.1, 95% CI 1.7-9.5, p=0.001). Low aerobic capacity in elderly adults was associated with adverse cardiovascular parameters, including a lower E/A ratio >0.8 (76% vs 35%; OR 4.1, 95% CI 1.7-9.5, P=0.001).
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