Key result
ACE2 deficiency increased atherosclerotic area compared to wild-type mice (23 vs 17 mm2, P<0.002) in low-density lipoprotein receptor-deficient mice fed a high-fat diet.
Why the study?
Does ACE2 deficiency increase atherosclerosis in low-density lipoprotein receptor-deficient mice?
Population
Male low-density lipoprotein receptor-deficient mice (whole body Ace2 or irradiated mice repopulated with…
Comparison
ACE2 deficiency (Ace2(-/y)) vs ACE2 wild-type (Ace2(+/y))
Design
Preclinical
Follow-up
3 months
Authors
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ACE2 deficiency promotes atherosclerosis in this mouse model; leaves open whether ACE2 modulation affects human plaque progression.
Does ACE2 deficiency increase atherosclerosis in low-density lipoprotein receptor-deficient mice?
Absolute Event Rate: 23% vs 17%
p-value: p=< 0.002
ACE2 deficiency in whole body or bone marrow-derived cells promotes atherosclerosis through regulation of Ang II/Ang-(1-7) peptides, suggesting a protective role for ACE2.
Thatcher et al. (2011) studied Atherosclerosis. ACE2 deficiency vs. Ace2(+/y) (wild-type ACE2) was evaluated on Atherosclerotic area (p=< 0.002). ACE2 deficiency increased atherosclerotic area compared to wild-type mice (23 vs 17 mm2, P<0.002) in low-density lipoprotein receptor-deficient mice fed a high-fat diet.