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November 4, 2013Cardiovascular Research

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation

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Why the study?

Does ACE2 deficiency promote the development of vascular lesions in models of vascular disease?

Population

Hyperlipidaemia-induced atherosclerosis in apolipoprotein E knockout mice, mechanical injury-induced…

Comparison

ACE2 deficiency vs ACE2(+) control

Design

Preclinical

Authors

MSMakoto SaharaMIMasayasu IkutomiTMToshihiro Morita

Discussion

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Overview

ACE2 may protect against vascular lesions in animal models; leaves open translation to human atherosclerosis or therapy.

Structured PICO

Does ACE2 deficiency promote the development of vascular lesions in models of vascular disease?

P
Population
Hyperlipidaemia-induced atherosclerosis in apolipoprotein E knockout (KO) mice, mechanical injury-induced arterial neointimal hyperplasia in C57Bl6 mice, and human macrophages and aortic vascular smooth muscle cells (VSMCs)
I
Intervention
ACE2 deficiency (via genetic knockout or ACE2-specific siRNA knockdown)
C
Comparator
ACE2(+) control
O
Outcome
Formation of vascular lesions (aortic atherosclerotic plaques and arterial neointima formation)surrogate

ACE2 deficiency promotes the development of vascular diseases through Ang-II-mediated vascular inflammation and JNK signaling activation, suggesting a protective role for ACE2.

Cite This Study

Sahara et al. (2013) studied this question.

synapsesocial.com/papers/6a6f779875498292b708dbdehttps://doi.org/10.1093/cvr/cvt245
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme 2 Deficiency in Whole Body or Bone Marrow–Derived Cells Increases Atherosclerosis in Low-Density Lipoprotein Receptor <sup>−/−</sup> Mice2011 · 80 citations
  2. 2Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling2014 · 97 citations
  3. 3ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production2012 · 84 citations
  4. 4Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis2008 · 309 citations
  5. 5Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells2010 · 123 citations