Key result
Cardiovascular disease patients with type 2 diabetes exhibited significantly lower peak oxygen uptake adjusted by skeletal muscle mass compared to those without diabetes (47.5 vs. 53.4 mL/kg/min, p=0.041).
Why the study?
The study aimed to evaluate oxygen uptake adjusted by total skeletal muscle mass in cardiovascular disease patients with or without type 2 diabetes mellitus.
Cross-Sectional (n=54)
No
Absolute Event Rate: 47.5% vs 53.4%
p-value: p=0.041
May suggest lower adjusted VO2 in DM patients with CVD; leaves open clinical relevance and need for prospective validation.
[Purpose] We aimed to evaluate oxygen uptake adjusted by total skeletal muscle mass in patients with cardiovascular disease with or without type 2 diabetes mellitus. [Participants and Methods] The participants included 54 males ≥50 years of age without heart failure who underwent cardiopulmonary exercise testing during cardiac rehabilitation. We divided the participants into two groups: patients with type 2 diabetes mellitus (DM group) and patients without type 2 diabetes mellitus (NDM group). [Results] We found no significant differences in age, weight, fat mass, or skeletal muscle mass between the groups. There were also no differences in cardiac function, body composition, and heart rate response. The DM group showed significantly lower peak oxygen uptake values adjusted by skeletal muscle mass, despite the absence of significant differences in skeletal muscle mass. A significant positive correlation was found between peak oxygen uptake and age, weight, and skeletal muscle mass. Stepwise regression analysis revealed that age, skeletal muscle mass, and medical history of diabetes were independent predictors of absolute peak oxygen uptake. [Conclusion] Peak oxygen uptake adjusted by skeletal muscle mass in patients with cardiovascular disease and type 2 diabetes mellitus is lower than that in those without type 2 diabetes mellitus.
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Takao et al. (2021) conducted a cross-sectional in Cardiovascular disease (n=54). Type 2 diabetes mellitus vs. Without type 2 diabetes mellitus was evaluated on Peak oxygen uptake adjusted by skeletal muscle mass (Peak VO2/SMM) in mL/kg/min (p=0.041). Cardiovascular disease patients with type 2 diabetes exhibited significantly lower peak oxygen uptake adjusted by skeletal muscle mass compared to those without diabetes (47.5 vs. 53.4 mL/kg/min, p=0.041).
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