Key result
Adiponectin and highly sensitive C-reactive protein levels are associated with the severity of coronary artery disease and serve as markers of poor prognosis in patients with CAD.
Why the study?
The study was conducted to estimate the effect of adiponectin and highly sensitive C-reactive protein levels on coronary artery disease severity in patients with chronic stable angina.
Are adiponectin and hsCRP levels associated with the severity of coronary artery disease in patients with chronic stable angina?
Systematic Review (n=29)
Are adiponectin and hsCRP levels associated with the severity of coronary artery disease in patients with chronic stable angina?
Adiponectin and hsCRP levels are associated with the severity of coronary artery disease and serve as markers of poor prognosis in patients with chronic stable angina.
May aid CAD severity assessment in stable angina; leaves open independent prognostic role pending prospective validation.
ObjectiveThe objective of our study was to estimate the effect of adiponectin (ADPN) and highly sensitive C-reactive protein (hsCRP) level on the severity of coronary artery disease (CAD) in patients with chronic stable angina.Materials and methodsMEDLINE databases (PubMed, Journal of Clinical Endocrinology and Metabolism, British Medical Journal, Journal of American College of Cardiology, and European Heart Journal) and also materials available in the internet were searched. The search was performed in the electronic databases from 2000 to 2017. The initial search presented 122 articles of which 29 met the inclusion criteria. The articles studied ADPN, hsCRP, and severity of CAD. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made by structured review with the results tabulated.FindingsIn total, 29 potentially relevant publications were included. The studies indicate an association between ADPN and hsCRP and severity of CAD in patients with CAD.ConclusionADPN and hsCRP are markers of poor prognosis in patients with CAD.
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Elsisy et al. (2019) conducted a systematic review in Coronary artery disease in patients with chronic stable angina (n=29). Adiponectin (ADPN) and highly sensitive C-reactive protein (hsCRP) was evaluated on Severity of coronary artery disease. Adiponectin and highly sensitive C-reactive protein levels are associated with the severity of coronary artery disease and serve as markers of poor prognosis in patients with CAD.
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