Key Points
- To examine the relationship between C-reactive protein and adiponectin in the bloodstream and adipose tissue in patients with coronary artery disease.
- Analyzed data from 101 male patients, including 71 with coronary atherosclerosis and 30 controls.
- Measured plasma hs-CRP and adiponectin levels, and conducted quantitative real-time polymerase chain reaction for mRNA analysis.
- Assessed correlation coefficients between hs-CRP and adiponectin levels.
- Plasma hs-CRP levels negatively correlated with adiponectin levels (r=-0.29, P<0.01).
- CAD patients showed lower adiponectin and higher hs-CRP levels compared to controls.
- Inverse correlation between CRP and adiponectin mRNA levels in adipose tissue (r=-0.89, P<0.01).
Structured PICO
PPopulation101 male patients (71 with angiographically documented coronary atherosclerosis, 30 with normal coronary angiogram) and adiponectin deficient/wild-type mice
CComparatorPatients with normal coronary angiogram (n=30) and wild-type mice
OOutcomeCorrelation between adiponectin and CRP levels in plasma and mRNA levels in adipose tissuesurrogate
There is a reciprocal association between adiponectin and CRP levels in human plasma and adipose tissue, which may participate in the development of atherosclerosis.