Key result
Low serum adiponectin and high HOMA-AD index linked to higher CAD risk.
Why the study?
The role of adiponectin resistance and the HOMA-AD index in the severity of coronary artery disease is not well understood.
Do adiponectin levels and HOMA-AD index correlate with the severity of coronary artery disease in patients with or without metabolic syndrome?
Cross-Sectional (n=130)
Do adiponectin levels and HOMA-AD index correlate with the severity of coronary artery disease in patients with or without metabolic syndrome?
Low adiponectin levels and elevated HOMA-AD index are associated with increased severity and risk of coronary artery disease, suggesting their potential utility as risk markers.
Answers are grounded in this paper and cite their sources.
May support adiponectin and HOMA-AD as CAD risk markers; leaves open prospective validation before clinical adoption.
BACKGROUND: The serum adiponectin level (AD), adiponectin resistance (AD-R) may reflect the degree of metabolic syndrome (MetS). The role parameter AD-R, The Homeostasis Model Assessment-Adiponectin (HOMA-AD) index on the coronary artery disease (CAD) severity is not still understood. OBJECTIVE: To determine adiponectin concentration and HOMA-AD index in patients with CAD with/without MetS and to evaluate their prognostic importance on severity of CAD. METHODS: This cross-sectional study involved selected 130 examinees which were divided into three groups: CAD+MetS, CAD-MetS, control group (no CAD/MetS). In all examinees values of biochemical and anthropometric parameters were determined. We analyzed the severity of coronary artery lesions from coronary angiography. Total serum adiponectin concentration was measured by ELISA. We calculated atherogenic Gensini scoring system, Duke prognostic index, and HOMA-AD-index. RESULTS: Serum adiponectin level was significantly lower in the group with CAD+MetS (p < 0.001) and in CAD-MetS group (p < 0.01), compared to the control group. The HOMA-AD index showed statistically significant positive correlation with the key parameters of MetS, as well as with the parameters of CAD, number of CAD and modified Gensini score. After applying logistic regression analysis the best predictors for CAD were: adiponectin, blood pressure, HOMA-IR index, and HOMA-AD index. The cut-off values of adiponectin ≤1506.38 pg/mL, HOMA-IR index ≥3.91 and HOMA-AD index ≥0.67 were associated with a higher risk of CAD. CONCLUSION: Patients with CAD with or without MetS had low adiponectin levels and this hypoadiponectinemia indicates that AD and HOMA-AD index may be a useful marker for identifying patients at risk for CAD.
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Stojanović et al. (2021) conducted a cross-sectional in Coronary Artery Disease (n=130). Adiponectin resistance and HOMA-AD index vs. Control group (no CAD/MetS) was evaluated on Serum adiponectin level (p=<0.001). Low serum adiponectin levels and a high HOMA-AD index were associated with a higher risk of coronary artery disease.
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