What question did this study set out to answer?

To examine the effects of the bile acid-binding polymer cholestyramine on plasma and liver cholesterol concentrations, cholesterol synthesis, and fecal bile acid excretion in rats under normal and cholesterol-supplemented diets.

November 1, 1963Experimental Biology and Medicine

Effect of Cholestyramine, A Bile Acid Binding Polymer on Plasma Cholesterol and Fecal Bile Acid Excretion in the Rat

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Authors

JHJesse W. HuffReata Pharmaceuticals (United States)JGJ. L. GilfillanMerck & Co., Inc., Rahway, NJ, USA (United States)VHV. M. HuntMerck & Co., Inc., Rahway, NJ, USA (United States)

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Implication

Experimental study demonstrates that cholestyramine increases bile acid excretion and blocks diet-induced cholesterol spikes in rats, highlighting its lipid-lowering mechanisms.

Key Points

To examine the effects of the bile acid-binding polymer cholestyramine on plasma and liver cholesterol concentrations, cholesterol synthesis, and fecal bile acid excretion in rats under normal and cholesterol-supplemented diets.
Administered cholestyramine to rats maintained on a normal standard diet.
Administered cholestyramine to rats fed a diet supplemented with cholesterol and cholic acid.
Measured plasma and liver cholesterol levels, hepatic de novo cholesterol synthesis rates, and fecal bile acid excretion profiles.
In rats receiving a normal diet, cholestyramine caused no change in plasma or liver cholesterol levels, but led to an increase in fecal bile acid excretion alongside elevated hepatic de novo cholesterol synthesis.
In rats given cholesterol and cholic acid, cholestyramine prevented diet-induced plasma cholesterol increases, slightly raised fecal bile acid excretion, and markedly elevated the dihydroxycholanic to cholic acid ratio.

Cite This Study

Huff et al. (1963) studied this question.

synapsesocial.com/papers/6a6e0ff2e5469ee92bdfe522 https://doi.org/10.3181/00379727-114-28674

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Implication

Experimental study demonstrates that cholestyramine increases bile acid excretion and blocks diet-induced cholesterol spikes in rats, highlighting its lipid-lowering mechanisms.

Effect of Cholestyramine, A Bile Acid Binding Polymer on Plasma Cholesterol and Fecal Bile Acid Excretion in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Cholestyramine, A Bile Acid Binding Polymer on Plasma Cholesterol and Fecal Bile Acid Excretion in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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