Key result
Activation of protein kinase C increases the plasma membrane expression of full-length, cardiac L-type calcium channel α1C within minutes, a process requiring the Ser1928 residue.
PKC regulation of cardiac CaV1.2 channels involves rapid changes in the channel's cellular fate, specifically increasing plasma membrane expression of full-length channels via mechanisms involving the C-terminus.
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Does not support clinical translation; leaves open PKC-Ser1928 targeting as a research direction in cardiac electrophysiology.
Raifman et al. (2017) studied this question. Protein kinase C (PKC) activation was evaluated on Plasma membrane expression of α1C protein. Activation of protein kinase C increases the plasma membrane expression of full-length, cardiac L-type calcium channel α1C within minutes, a process requiring the Ser1928 residue.
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