Key result
Phosphorylation of reconstituted cardiac Ca2+ channels by PKA increased Ca2+ efflux by about 70%, whereas PKC failed to modulate Ca2+ efflux.
PKA, but not PKC, directly regulates cardiac L-type Ca2+ channels through phosphorylation of the alpha 1 subunit in a reconstituted system.
No takes yet. Share an insight, caveat, or question.
PKA phosphorylation enhances Ca2+ efflux in reconstituted channels; leaves open in vivo relevance and any clinical implications.
Kameyama et al. (1996) studied Cardiac Ca2+ channel regulation. cAMP-dependent protein kinase (PKA) vs. Protein kinase C (PKC) was evaluated on Dihydropyridine-sensitive Ca2+ efflux. Phosphorylation of reconstituted cardiac Ca2+ channels by PKA increased Ca2+ efflux by about 70%, whereas PKC failed to modulate Ca2+ efflux.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: