Key result
Exposure of excised patches to PKA + ATP, okadaic acid, or cAMP + ATP significantly increased Ca(V)1.2 channel activity recovery by CaM + ATP compared to CaM + ATP alone.
Absolute Event Rate: 114% vs 9%
PKA and phosphatases attached to or near the CaV1.2 channel regulate basal channel activity, likely by modulating dynamic CaM interaction.
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Findings in excised patches warrant caution before clinical translation; leaves open roles of PKA/phosphatases in intact myocyte CaV1.2 regulation.
Xu et al. (2015) studied this question. PKA + ATP, okadaic acid, or cAMP + ATP vs. CaM + ATP alone was evaluated on Ca(V)1.2 channel activity recovery. Exposure of excised patches to PKA + ATP, okadaic acid, or cAMP + ATP significantly increased Ca(V)1.2 channel activity recovery by CaM + ATP compared to CaM + ATP alone.
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