Key result
Four weeks of high-intensity interval training significantly increased the expression of anti-apoptotic Bcl-2 and decreased the expression of pro-apoptotic Bax in the heart tissue of diabetic rats.
Why the study?
Diabetes is a major risk factor for cardiovascular disease, and this study investigated the effect of high-intensity interval training on cardiomyocyte apoptosis factors Bcl-2 and Bax in diabetic rats.
Does high-intensity interval training improve the expression of apoptotic genes (Bcl-2 and Bax) in the heart tissue of diabetic rats?
Does high-intensity interval training improve the expression of apoptotic genes (Bcl-2 and Bax) in the heart tissue of diabetic rats?
High-intensity interval training significantly increases anti-apoptotic Bcl-2 and decreases pro-apoptotic Bax expression in the heart tissue of diabetic rats, suggesting a protective effect against myocardial cell death.
HIIT beneficially modulates apoptotic markers in diabetic rat hearts; leaves open translation to human CV outcomes.
Background and Objectives: Diabetes is one of the most common diseases and a major risk factor for cardiovascular disease. Studies have shown that regular exercise can affect apoptosis in cardiomyocytes. The purpose of this study was to investigate the effect of high-intensity interval training on the expression of Bcl-2 and Bax as important apoptosis factors in diabetic rats.
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Ramezani et al. (2019) studied Type 2 diabetes (n=20). High-intensity interval training vs. No training was evaluated on Expression of Bcl-2 and Bax in heart tissue (p=0.002 for Bax, 0.009 for Bcl-2). Four weeks of high-intensity interval training significantly increased the expression of anti-apoptotic Bcl-2 and decreased the expression of pro-apoptotic Bax in the heart tissue of diabetic rats.
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