Key result
Preexisting hypertension is associated with a higher risk of developing severe outcomes from COVID-19, potentially linked to endothelial dysfunction and renin-angiotensin system imbalance.
Why the study?
Observational studies showed that a majority of patients with COVID-19 have preexisting hypertension, raising questions regarding their relationship and underlying mechanisms.
Preexisting hypertension may increase the risk of severe COVID-19 outcomes through mechanisms involving renin-angiotensin system imbalance and endothelial dysfunction.
Answers are grounded in this paper and cite their sources.
May support risk stratification by hypertension status in COVID-19; hypothesis-generating for endothelial and RAS-targeted therapies.
It has been a year since the coronavirus disease 2019 (COVID-19) was declared pandemic and wreak havoc worldwide. Despite meticulous research has been done in this period, there are still much to be learn from this novel coronavirus. Globally, observational studies have seen that majority of the patients with COVID-19 have preexisting hypertension. This raises the question about the possible relationship between COVID-19 and hypertension. This review summarizes the current understanding of the link between hypertension and COVID-19 and its underlying mechanisms.
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Muhamad et al. (2021) conducted a review in COVID-19 and Hypertension. Hypertension vs. Normotension was evaluated. Preexisting hypertension is associated with a higher risk of developing severe outcomes from COVID-19, potentially linked to endothelial dysfunction and renin-angiotensin system imbalance.
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