Key result
Local tissue hypoxia, induced by systemic hypoxia or hypoperfusion, greatly attenuated LBNP-induced decreases in muscle oxygenation in human skeletal muscle.
Why the study?
Does tissue hypoxia play a role in the attenuation of sympathetic vasoconstriction in contracting human skeletal muscle?
Population
19 human subjects
Comparison
Reflex sympathetic activation with lower body… vs Resting forearm and varying intensities of…
Design
Other
Authors
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Local hypoxia may preserve muscle oxygenation during hypoperfusion; leaves open clinical relevance and need for prospective validation.
Does tissue hypoxia play a role in the attenuation of sympathetic vasoconstriction in contracting human skeletal muscle?
Local tissue hypoxia is involved in the metabolic attenuation of sympathetic vasoconstriction in the microcirculation of exercising human skeletal muscle, independent of the cyclo-oxygenase pathway.
Hansen et al. (2000) studied this question. Tissue hypoxia (systemic hypoxia or hypoperfusion) vs. Resting muscle / normoxia was evaluated on Decrease in muscle oxygenation (ΔtHbO2+MbO2) in response to lower body negative pressure (LBNP). Local tissue hypoxia, induced by systemic hypoxia or hypoperfusion, greatly attenuated LBNP-induced decreases in muscle oxygenation in human skeletal muscle.
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