Key result
Lower body negative pressure reduced baseline forearm vascular conductance by 34% (P<0.05), but this vasoconstrictor effect was blunted to a 15% reduction during moderate and heavy exercise (P<0.01).
Why the study?
Does lower body negative pressure alter forearm vascular conductance during early handgrip exercise in human subjects?
Does lower body negative pressure alter forearm vascular conductance during early handgrip exercise in human subjects?
p-value: p=<0.01
Sympatholysis occurs early in exercise, as moderate and heavy handgrip exercise diminishes the vasoconstrictor effects of lower body negative pressure.
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May guide vascular study interpretation during exercise; extends mechanistic insights but leaves open patient applicability.
DeLorey et al. (2002) studied this question. Lower body negative pressure (LBNP) vs. Control was evaluated on Forearm vascular conductance (VC) and forearm blood flow (FBF) (p=<0.01). Lower body negative pressure reduced baseline forearm vascular conductance by 34% (P<0.05), but this vasoconstrictor effect was blunted to a 15% reduction during moderate and heavy exercise (P<0.01).
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