Key result
Rhythmic handgrip exercise progressively attenuated the lower body negative pressure-induced decrease in muscle oxygenation as exercise intensity increased from 10% to 30% MVC (p<0.01).
Why the study?
Does exercise intensity influence functional sympatholysis (measured by muscle oxygenation) during mild rhythmic handgrip exercise in healthy volunteers?
Does exercise intensity influence functional sympatholysis (measured by muscle oxygenation) during mild rhythmic handgrip exercise in healthy volunteers?
Absolute Event Rate: 4.6% vs 16.4%
p-value: p=<0.01
Functional sympatholysis during mild rhythmic handgrip exercise is dependent on exercise intensity, progressively attenuating sympathetic vasoconstriction as intensity increases.
Hypothesis-generating in healthy volunteers; leaves open clinical translation to patients with sympathetic dysregulation.
This study attempts to clarify whether intensity of exercise influences functional sympatholysis during mild rhythmic handgrip exercise (RHG). We measured muscle oxygenation in both exercising and non-exercising muscle in the same arm in 11 subjects using near infrared spectroscopy (NIRS), heart rate, and blood pressure. We used the total labile signal to assess the relative muscle oxygenation by occlusion for 6 min. Subjects performed RHG (20 times/min) for 6 min at 10%, 20%, and 30% of maximal voluntary contraction (MVC) at random. We used a non-hypotensive lower body negative pressure (LBNP) of 220 mmHg for 2 min to elicit reproducible enhancement in muscle sympathetic nerve activity (MSNA) at rest and during RHG. LBNP caused decreases of 16.4% and 17.7% of the level of muscle oxygenation at rest (pre) in exercising (forearm) and non-exercising (upper arm) muscle respectively. Muscle oxygenation in non-exercising muscle with the application of LBNP during RHG did not change significantly at each intensity. In contrast, the decrease in muscle oxygenation in exercising muscle attenuated progressively as exercise intensity increased (10% MVC 8.8+/-2.8%, 20% MVC 7.1+/-2.0%, 30% MVC 4.6+/-3.0%), when LBNP was applied during RHG. The attenuation of the decrease in muscle oxygenation due to LBNP during RHG at 10%, 20%, and 30% was significantly different from that at rest (p<0.01). These findings indicate that functional sympatholysis during mild RHG might be attributed to exercise intensity.
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Watanabe et al. (2007) studied Healthy volunteers (n=11). Rhythmic handgrip exercise with lower body negative pressure vs. Rest was evaluated on Decrease in muscle oxygenation in exercising muscle during lower body negative pressure (p=<0.01). Rhythmic handgrip exercise progressively attenuated the lower body negative pressure-induced decrease in muscle oxygenation as exercise intensity increased from 10% to 30% MVC (p<0.01).
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