Key result
Intracarotid infusions of 1 M NaCl, 2 M fructose, and 2 M sucrose caused marked inhibition of water diuresis due to ADH release, while glycerol, galactose, glucose, and urea had weak or no effect.
Why the study?
Do intracarotid infusions of various hypertonic solutions alter the antidiuretic response in conscious goats?
Do intracarotid infusions of various hypertonic solutions alter the antidiuretic response in conscious goats?
The antidiuretic response to intracarotid hypertonic infusions in goats varies by solute, suggesting mechanisms that appear incompatible with the current osmoreceptor theory.
Refines osmoreceptor selectivity models; leaves open human translation and clinical relevance.
Various hypertonic equi‐osmolal solutions were infused via permanently implanted catheters into the external carotid artery of conscious, hydrated goats. The infusions (1.5 ml/min) of 1 M NaCl, 2 M fructose and 2 M sucrose caused a marked inhibition of the water diuresis. The effect was evidently due to a release of antidiuretic hormone (ADH) since it disappeared after induction of diabetes insipidus. No antidiuretic response occurred during infusions of either 2 M glycerol or 2 M galactose, while a weak response was seen after infusions of 2 M glucose. Infusions of 2 M urea gave inconsistent results. Infusions of hypertonic fructose into the 3rd ventricle of the hydrated goat did not change the course of the water diuresis, whereas the corresponding infusion of equi‐osmolal NaCl effectively released ADH. It is concluded that neither changes in the blood osmolalities as such, nor different penetration rates across the blood‐brain barrier can explain the results, some of which appear incompatible with the current osmoreceptor theory.
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Eriksson et al. (1971) studied Hydrated goats. Intracarotid infusions of various hypertonic equi-osmolal solutions was evaluated on Antidiuretic response (inhibition of water diuresis). Intracarotid infusions of 1 M NaCl, 2 M fructose, and 2 M sucrose caused marked inhibition of water diuresis due to ADH release, while glycerol, galactose, glucose, and urea had weak or no effect.
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