Key result
Radiofrequency catheter ablation for atrial fibrillation was followed by the development of a giant left atrial thrombus causing brain infarction and amaurosis fugax 3 months post-procedure in a patient with undiagnosed essential thrombocythemia and cancer.
Case Report (n=1)
No
This case highlights the risk of giant thrombus formation on the ablation line after RFCA for AF, even with adequate anticoagulation, particularly in patients with underlying hypercoagulable states.
Alerts to possible post-ablation thromboembolism in undiagnosed myeloproliferative disorders; hypothesis-generating case requiring prospective validation.
Radiofrequency catheter ablation (RFCA) is a standard treatment for atrial fibrillation (AF). However, RFCA is associated with perioperative problems, such as systemic embolization, and asymptomatic brain infarction is frequently detected by magnetic resonance imaging immediately after RFCA for AF.1,2 Most embolic adverse events associated with RFCA are presumably caused by microbubbles or thrombus formation.3 A previous in vivo study suggested that endothelial hyperthermic injury by RFCA induces thrombus formation.
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Noiri et al. (2021) conducted a case report in Atrial fibrillation (n=1). Radiofrequency catheter ablation was evaluated on Development of giant left atrial thrombus. Radiofrequency catheter ablation for atrial fibrillation was followed by the development of a giant left atrial thrombus causing brain infarction and amaurosis fugax 3 months post-procedure in a patient with undiagnosed essential thrombocythemia and cancer.
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