Key result
Mild aortic stenosis combined with high-output cardiac failure can cause Heyde syndrome, leading to a vicious cycle where anemia worsens blood loss.
Even mild aortic stenosis can lead to Heyde syndrome in the setting of high-output cardiac failure or anemia, creating a vicious cycle of worsening blood loss.
Even mild aortic stenosis may trigger Heyde syndrome in high-output states; this case leaves open the need for prospective validation.
•High gradients along a stenosed aortic valve are the cause of Heyde syndrome.•With high-output cardiac failure, even mild aortic stenosis can cause Heyde syndrome.•When anemia causes a high-output state, this can worsen blood bloss in Heyde syndrome.
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Schwaiger et al. (2019) studied this question. Mild aortic stenosis combined with high-output cardiac failure can cause Heyde syndrome, leading to a vicious cycle where anemia worsens blood loss.
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