Key result
Increased nutritive blood flow via norepinephrine or angiotensin II enhanced the exchange of glucose and lactate by improving glucose supply to and lactate removal from the interstitium in rat hindlimbs.
Why the study?
Does varying nutritive blood flow alter interstitial glucose and lactate exchange in perfused rat hindlimbs?
Does varying nutritive blood flow alter interstitial glucose and lactate exchange in perfused rat hindlimbs?
Increased nutritive blood flow enhances the exchange of glucose and lactate by improving glucose supply and lactate removal in the interstitium.
Preclinical data preclude practice change; extends mechanisms of nutritive flow on muscle metabolite exchange but requires human validation.
Microdialysis was used to assess the interstitial concentrations of glucose and lactate in the constant-flow-perfused rat hindlimb under varying levels of nutritive flow controlled by vasoconstrictors. Increased nutritive flow was achieved by norepinephrine (NE) or angiotensin II (ANG II) and decreased nutritive flow by serotonin (5-HT). NE and ANG II increased oxygen and glucose uptake as well as hindlimb lactate release by 50%. 5-HT decreased oxygen uptake by 15% but had no significant effect on glucose uptake or hindlimb lactate release. Microdialysis recovery of glucose and lactate was significantly elevated by NE and ANG II and decreased by 5-HT. The calculated interstitial concentration of glucose was increased by NE and ANG II but decreased by 5-HT. The interstitial concentration of lactate was decreased by NE and ANG II but increased by 5-HT. In all cases, nitroprusside reversed the effects of the vasoconstrictors. These data indicate that increased nutritive blood flow enhances the exchange of glucose and lactate by improving the supply of glucose to and the removal of lactate from the interstitium.
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Newman et al. (2002) studied this question. Vasoconstrictors (norepinephrine, angiotensin II, serotonin) was evaluated on Interstitial concentrations of glucose and lactate, oxygen and glucose uptake, and lactate release. Increased nutritive blood flow via norepinephrine or angiotensin II enhanced the exchange of glucose and lactate by improving glucose supply to and lactate removal from the interstitium in rat hindlimbs.
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