Key result
Inhibition of nitric oxide synthesis with L-NAME potentiated the hypertensive response to chronic glucose infusion in rats, raising mean arterial pressure to 155+/-8 mm Hg by day 6.
Why the study?
Does inhibition of nitric oxide synthesis with L-NAME potentiate hypertension during chronic glucose infusion in rats?
Does inhibition of nitric oxide synthesis with L-NAME potentiate hypertension during chronic glucose infusion in rats?
Nitric oxide production plays a critical role in counteracting the hypertensive response to chronic glucose infusion in a rat model.
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NO inhibition exacerbates glucose-induced hypertension in rats; hypothesis-generating for endothelial roles in human hyperglycemia but should not change practice.
Claxton et al. (2000) studied Hypertension (n=17). L-NAME vs. Glucose infusion alone was evaluated on Mean arterial pressure. Inhibition of nitric oxide synthesis with L-NAME potentiated the hypertensive response to chronic glucose infusion in rats, raising mean arterial pressure to 155+/-8 mm Hg by day 6.
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