Key result
Cotreatment with NSAIDs (OR 8; 95% CI 2.09-30.58), anticoagulants, stroke, male gender, and ulcer history were independent risk factors for gastroduodenal ulcer in low-dose aspirin consumers.
Why the study?
What are the clinical risk factors for gastroduodenal ulcer in patients taking low-dose aspirin?
Population
159 patients taking low-dose aspirin who underwent upper digestive endoscopy
Comparison
Presence of clinical risk factors vs Absence of these clinical risk factors
Design
Case-control
Authors
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May inform ulcer risk stratification in aspirin users; leaves open prospective validation before practice change.
Case-Control (n=159)
What are the clinical risk factors for gastroduodenal ulcer in patients taking low-dose aspirin?
Odds Ratio: 8 (95% CI 2.09–30.58)
Concomitant use of NSAIDs or anticoagulants, male gender, and history of stroke or peptic ulcer significantly increase the risk of gastroduodenal ulcer in patients taking low-dose aspirin.
Negovan et al. (2016) conducted a case-control in Gastroduodenal Ulcer (n=159). Cotreatment with NSAIDs vs. No cotreatment with NSAIDs was evaluated on Ulcer on endoscopy (OR 8, 95% CI 2.09-30.58). Cotreatment with NSAIDs (OR 8; 95% CI 2.09-30.58), anticoagulants, stroke, male gender, and ulcer history were independent risk factors for gastroduodenal ulcer in low-dose aspirin consumers.
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