Key result
Chronic aspirin use (1 g/day) significantly increased the risk of peptic ulcer hospitalization compared to placebo (RR 7.7; 95% CI 2.7-21.7; P<0.0001).
Why the study?
Does chronic aspirin use (1 g per day) increase the risk of duodenal and gastric ulcer hospitalizations in subjects with myocardial infarction?
Population
n=4,524 subjects from the Aspirin Myocardial Infarction Study
Comparison
Aspirin 1 g per day vs Placebo
Design
RCT, randomized, double-blind
Follow-up
3 years
Authors
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High-dose aspirin increases peptic ulcer hospitalization risk; confirms gastrotoxicity and supports gastroprotection in chronic users.
RCT (n=4,524)
Double-blind
randomized
Does chronic aspirin use (1 g per day) increase the risk of duodenal and gastric ulcer hospitalizations in subjects with myocardial infarction?
Relative Risk: 7.7 (95% CI 2.7–21.7)
p-value: p=<0.0001
Chronic use of 1 g/day aspirin significantly increases the risk of hospitalization for both duodenal and gastric ulcers.
Kurata et al. (1990) conducted an RCT in Myocardial Infarction (n=4,524). Aspirin vs. Placebo was evaluated on Peptic ulcer hospitalization (RR 7.7, 95% CI 2.7-21.7, p=<0.0001). Chronic aspirin use (1 g/day) significantly increased the risk of peptic ulcer hospitalization compared to placebo (RR 7.7; 95% CI 2.7-21.7; P<0.0001).
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