Key result
TGF-β1 promotes fibrosis by activating Smad3, but attenuates calcification by inhibiting Smad1/5/8 and Wnt/β-catenin signaling in a 3D valvular tissue model.
Why the study?
To investigate the role of transforming growth factor (TGF)-beta1 in calcific aortic valve disease pathogenesis.
TGF-β1 has a dual role in calcific aortic valve disease, promoting fibrosis while attenuating calcification, which questions its general phase-independent disease-promoting role.
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May inform TGF-β1-targeted therapies in calcific aortic valve disease; leaves open clinical translation pending in vivo validation.
Jenke et al. (2020) studied Calcific aortic valve disease. Transforming growth factor (TGF)-β1 was evaluated on Fibrosis and calcification of valvular tissue. TGF-β1 promotes fibrosis by activating Smad3, but attenuates calcification by inhibiting Smad1/5/8 and Wnt/β-catenin signaling in a 3D valvular tissue model.
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