Key result
Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts, suggesting a potential regulatory mechanism of valvular calcification.
Why the study?
Does TNF-alpha promote an osteoblast-like phenotype in human aortic valve myofibroblasts?
Does TNF-alpha promote an osteoblast-like phenotype in human aortic valve myofibroblasts?
TNF-alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts, providing mechanistic evidence that inflammation actively regulates aortic valve calcification.
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Supports inflammation-driven valvular calcification; leaves open whether TNF-alpha targeting alters progression in patients.
Kaden et al. (2005) studied Valvular calcification. Tumor necrosis factor alpha was evaluated. Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts, suggesting a potential regulatory mechanism of valvular calcification.
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