Key result
In an analysis of 58 human valves, calcified rheumatic valves exhibited complex calcification, upregulated osteoblast markers, and neoangiogenesis compared to normal and degenerative valves.
Observational (n=58)
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No immediate clinical implications for valve management; hypothesis-generating for osteoblast and angiogenic targets in rheumatic disease.
Rajamannan et al. (2005) conducted an observational in Rheumatic valve calcification (n=58). Rheumatic valves vs. Normal human valves and degenerative mitral valve leaflets was evaluated on Presence of calcification, osteoblast markers, and neoangiogenesis. In an analysis of 58 human valves, calcified rheumatic valves exhibited complex calcification, upregulated osteoblast markers, and neoangiogenesis compared to normal and degenerative valves.
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