Key result
Loss of Tgfβ1 in the endothelium leads to reduced Sox9 expression and calcific aortic valve disease, indicating reduced nuclear localization of Sox9 is an early indicator of calcification.
Endothelial-derived Tgfβ1 signaling maintains Sox9 nuclear localization in valve interstitial cells, preventing calcification and suggesting a potential therapeutic target for calcific aortic valve disease.
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May flag early aortic valve calcification via Sox9 localization; leaves open endothelial Tgfβ1 as therapeutic target.
Huk et al. (2015) studied Aortic valve disease and calcification. Loss of Tgfβ1 in the endothelium vs. Normal Tgfβ1 signaling was evaluated on Sox9 expression, nuclear localization, and calcific nodule formation. Loss of Tgfβ1 in the endothelium leads to reduced Sox9 expression and calcific aortic valve disease, indicating reduced nuclear localization of Sox9 is an early indicator of calcification.
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