Key result
Endocardial regulation, driven by Notch and BMP signaling, plays a crucial role in cardiac development and the pathogenesis of congenital heart defects such as bicuspid aortic valves.
Why the study?
The endocardium plays a crucial role in cardiac development but has been comparatively less studied than other cardiac cell types.
Design
Review
Authors
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Endocardial developmental insights remain preclinical; leaves open translation to congenital heart disease therapies.
Understanding cellular and molecular processes in the endocardium is vital for developing stem cell-derived models for disease modeling and regenerative medicine in congenital heart defects.
Feulner et al. (2022) conducted a review in Cardiac development and congenital heart defects. Endocardial regulation, driven by Notch and BMP signaling, plays a crucial role in cardiac development and the pathogenesis of congenital heart defects such as bicuspid aortic valves.
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