Key result
Endocardial cells act as sensors and signal transducers of biophysical forces and as angiocrine signalling centres involved in myocardial morphogenesis, regeneration, and reprogramming.
Design
Review
Authors
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Endocardial mechanosensing and angiocrine signaling merit targeted study; leaves open therapeutic translation in cardiac disease.
This review highlights the emerging role of the endocardium as a sensor and signal transducer of biophysical forces and an angiocrine signalling centre in cardiac development and disease.
Haack et al. (2016) conducted a review in Cardiac morphogenesis and endocardial development. Endocardial cells act as sensors and signal transducers of biophysical forces and as angiocrine signalling centres involved in myocardial morphogenesis, regeneration, and reprogramming.
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