Key result
Administration of RU486 to transgenic mice expressing a cardiac-specific Cre fusion protein induced post-translational recombination in the postnatal myocardium.
The alphaMHC-CrePR1 system allows for inducible, cardiac-specific gene targeting in postnatal mice using RU486, avoiding early embryonic lethality.
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RU486-inducible Cre enables postnatal myocardial gene targeting in mice; extends temporal genetic models for cardiac research but leaves clinical translation open.
Minamino et al. (2001) studied this question. RU486 vs. Vehicle was evaluated on Prevalence of beta-galactosidase-positive cells (Cre-mediated excision). Administration of RU486 to transgenic mice expressing a cardiac-specific Cre fusion protein induced post-translational recombination in the postnatal myocardium.
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